MYSM1 anticorps (N-Term)
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- Antigène Voir toutes MYSM1 Anticorps
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MYSM1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- KLIGSRTVLQ VKSYARQYFK NKVKCGLDKE TPNQKTGHNL QVKNEDKGTK
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MYSM1
- Top Product
- Discover our top product MYSM1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 828 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
- Autre désignation
- MYSM1 (MYSM1 Produits)
- Synonymes
- anticorps 2A-DUB, anticorps 2ADUB, anticorps RP4-592A1.1, anticorps C130067A03Rik, anticorps C530050H10Rik, anticorps RGD1311787, anticorps 2adub, anticorps Myb like, SWIRM and MPN domains 1, anticorps myb-like, SWIRM and MPN domains 1, anticorps Myb like, SWIRM and MPN domains 1 L homeolog, anticorps MYSM1, anticorps Mysm1, anticorps mysm1.L
- Sujet
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MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Alias Symbols: 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1
Protein Interaction Partner: UBC, DICER1, SUMO2, TUBB1, WDR77, STK38, PRMT5, KAT2B, HIST2H2AC, RBM10, KIF11, HSPA1A, HNRNPH1, EEF1A1,
Protein Size: 828 - Poids moléculaire
- 91 kDa
- ID gène
- 114803
- NCBI Accession
- NM_001085487, NP_001078956
- UniProt
- Q5VVJ2
- Pathways
- Chromatin Binding
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