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MACROD1 anticorps (N-Term)

MACROD1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2791083
  • Antigène Tous les produits MACROD1
    MACROD1 (MACRO Domain Containing 1 (MACROD1))
    Épitope
    • 5
    • 1
    N-Term
    Reactivité
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval
    Hôte
    • 6
    Lapin
    Clonalité
    • 6
    Polyclonal
    Conjugué
    • 2
    • 2
    • 1
    • 1
    Cet anticorp MACROD1 est non-conjugé
    Application
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA
    Homologie
    Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 325 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MACROD1 (MACRO Domain Containing 1 (MACROD1))
    Autre désignation
    MACROD1 (MACROD1 Produits)
    Synonymes
    anticorps lrp16, anticorps d930010j01rik, anticorps LRP16, anticorps AI604841, anticorps AW743046, anticorps D930010J01Rik, anticorps Lrp16, anticorps MACRO domain containing 1, anticorps MACRO domain containing 1 L homeolog, anticorps MACROD1, anticorps macrod1, anticorps macrod1.L, anticorps Macrod1
    Sujet
    MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
    Alias Symbols: LRP16
    Protein Interaction Partner: BAG3, EPB41,
    Protein Size: 325
    Poids moléculaire
    36 kDa
    ID gène
    28992
    NCBI Accession
    NM_014067, NP_054786
    UniProt
    Q9BQ69
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