MACROD1 anticorps (N-Term)
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- Antigène Tous les produits MACROD1
- MACROD1 (MACRO Domain Containing 1 (MACROD1))
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Épitope
- N-Term
- Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MACROD1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA
- Homologie
- Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 325 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MACROD1 (MACRO Domain Containing 1 (MACROD1))
- Autre désignation
- MACROD1 (MACROD1 Produits)
- Synonymes
- anticorps lrp16, anticorps d930010j01rik, anticorps LRP16, anticorps AI604841, anticorps AW743046, anticorps D930010J01Rik, anticorps Lrp16, anticorps MACRO domain containing 1, anticorps MACRO domain containing 1 L homeolog, anticorps MACROD1, anticorps macrod1, anticorps macrod1.L, anticorps Macrod1
- Sujet
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MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
Alias Symbols: LRP16
Protein Interaction Partner: BAG3, EPB41,
Protein Size: 325 - Poids moléculaire
- 36 kDa
- ID gène
- 28992
- NCBI Accession
- NM_014067, NP_054786
- UniProt
- Q9BQ69
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