PLD6 anticorps (C-Term)

N° du produit ABIN2791346

Détail du produit anti-PLD6 anticorps

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLD6 est non-conjugé

Application: Western Blotting (WB)

Séquence: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 252 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PLD6

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Autre désignation: PLD6 (PLD6 Produits)

Synonymes: anticorps ZUC, anticorps 4933433K01Rik, anticorps Gm10, anticorps Zuc, anticorps mZuc, anticorps mitoPLD, anticorps pld6, anticorps fc55d08, anticorps wu:fc55d08, anticorps phospholipase D family member 6, anticorps phospholipase D family, member 6, anticorps phospholipase D family member 6 S homeolog, anticorps PLD6, anticorps Pld6, anticorps pld6.S, anticorps pld6

Sujet: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
Alias Symbols: -
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 252

Poids moléculaire: 28 kDa

ID gène: 201164

NCBI Accession: NM_178836, NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization