Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

VHLL anticorps (N-Term)

VHLL Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2791981
  • Antigène Voir toutes VHLL Anticorps
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    Épitope
    • 6
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain
    Hôte
    • 6
    • 3
    Lapin
    Clonalité
    • 7
    • 2
    Polyclonal
    Conjugué
    • 5
    • 2
    • 1
    • 1
    Cet anticorp VHLL est non-conjugé
    Application
    • 6
    • 3
    • 1
    Western Blotting (WB)
    Séquence
    PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR
    Homologie
    Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL
    Top Product
    Discover our top product VHLL Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeat freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    Autre désignation
    VHLL (VHLL Produits)
    Synonymes
    anticorps VHLP, anticorps VLP, anticorps VHL like, anticorps VHLL
    Sujet
    Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
    Alias Symbols: VHLP, VLP
    Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
    Protein Size: 139
    Poids moléculaire
    15 kDa
    ID gène
    391104
    NCBI Accession
    NM_001004319, NP_001004319
    UniProt
    Q6RSH7
Vous êtes ici:
Support technique