Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

NLRC4 anticorps (C-Term)

NLRC4 Reactivité: Humain, Souris, Rat, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2792097
  • Antigène Voir toutes NLRC4 Anticorps
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    Épitope
    • 9
    • 9
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    Humain, Souris, Rat, Cobaye
    Hôte
    • 26
    • 10
    • 2
    Lapin
    Clonalité
    • 27
    • 11
    Polyclonal
    Conjugué
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NLRC4 est non-conjugé
    Application
    • 27
    • 17
    • 10
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    QLNLAGNRVS SDGWLAFMGV FENLKQLVFF DFSTKEFLPD PALVRKLSQV
    Specificité
    This antibody will recognize NLRC4 isoform 1 (116kD) and isoform 2 (40kD).
    Homologie
    Guinea Pig: 80%, Human: 100%, Mouse: 86%, Rat: 80%
    Attributs du produit
    This is a rabbit polyclonal antibody against NLRC4. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human NLRC4
    Top Product
    Discover our top product NLRC4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 1024 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hughes, Vivar, Kennis, Pratt-Thomas, Lowe, Shaner, Nietert, Spruill, Purves: "Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation." dans: American journal of physiology. Renal physiology, Vol. 306, Issue 3, pp. F299-308, (2014) (PubMed).

  • Antigène
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    Autre désignation
    NLRC4 (NLRC4 Produits)
    Synonymes
    anticorps CARD12, anticorps CLAN, anticorps CLAN1, anticorps CLANA, anticorps CLANB, anticorps CLANC, anticorps CLAND, anticorps CLR2.1, anticorps IPAF, anticorps 9530011P19Rik, anticorps Card12, anticorps NLR family CARD domain containing 4, anticorps NLR family, CARD domain containing 4, anticorps NLRC4, anticorps Nlrc4
    Sujet
    In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
    Alias Symbols: CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CARD12, CLR2.1
    Protein Interaction Partner: UBC, XK, ALB, NLRC4, PSMC5, CASP8, NLRP4, PYCARD, NOD2, BCL10, CASP1, NLRP1, NLRP3, NOD1, NAIP,
    Protein Size: 1024
    Poids moléculaire
    116 kDa
    ID gène
    58484
    NCBI Accession
    NM_021209, NP_067032
    UniProt
    Q9NPP4
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
Vous êtes ici:
Support technique