CDKN1B anticorps (C-Term)

N° du produit ABIN2792168

Détail du produit anti-CDKN1B anticorps

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN1B est non-conjugé

Application: Western Blotting (WB)

Séquence: EQCAGIRKRP ATDDSSTQNK RANRTEENVS DGSPNAGSVE QTPKKPGLRR

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CDKN1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 198 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CDKN1B (ABIN2792168)

Azzato, Driver, Lesueur, Shah, Greenberg, Easton, Teschendorff, Caldas, Caporaso, Pharoah: "Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort." dans: Breast cancer research : BCR, Vol. 10, Issue 3, pp. R47, (2008) (PubMed).

Détails sur CDKN1B

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Autre désignation: CDKN1B (CDKN1B Produits)

Synonymes: anticorps CDKN4, anticorps KIP1, anticorps MEN1B, anticorps MEN4, anticorps P27KIP1, anticorps cdkn1b, anticorps sb:cb611, anticorps wu:fb63g10, anticorps wu:fb64g10, anticorps wu:fe18e03, anticorps CDKN1B, anticorps Kip1, anticorps p27, anticorps FAM14D, anticorps ISG12, anticorps ISG12A, anticorps P27, anticorps Cdki1b, anticorps AA408329, anticorps AI843786, anticorps p27Kip1, anticorps cdkn1bl, anticorps cyclin dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Bb, anticorps interferon alpha inducible protein 27, anticorps cyclin-dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Ba, anticorps CDKN1B, anticorps cdkn1bb, anticorps IFI27, anticorps Cdkn1b, anticorps cdkn1ba

Sujet: CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: CCND1, UBC, SGK1, PSMB1, CDK4, SKP2, CDK5, CDK3, CDK2, CDK1, SKP1, CKS1B, CCNE1, CCND3, CAMK1, YWHAQ, CCNA2, ABL1, TSC2, LYN, STMN1, RHOA, RPS6KA1, IRF1, KPNA6, CCNE2, CCNA1, VCP, SRC, MAPK10, MAPK8, CDC34, CDK6, RCHY1, COPS5, CUL1, HIST1H1A, CUL4A, JAK2,
Protein Size: 198

Poids moléculaire: 22 kDa

ID gène: 1027

NCBI Accession: NM_004064, NP_004055

UniProt: P46527

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy