VAV1 anticorps (Middle Region)
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- Antigène Voir toutes VAV1 Anticorps
- VAV1 (Vav 1 Oncogene (VAV1))
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Épitope
- Middle Region
- Reactivité
- Humain, Rat, Souris, Chien, Cheval, Boeuf (Vache), Porc, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VAV1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
- Réactivité croisée
- Boeuf (Vache), Chien, Humain, Souris, Rat (Rattus)
- Homologie
- Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%
- Attributs du produit
- This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human VAV1
- Top Product
- Discover our top product VAV1 Anticorps primaire
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- Indications d'application
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WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator. - Commentaires
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Antigen size: 845 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- VAV1 (Vav 1 Oncogene (VAV1))
- Autre désignation
- VAV1 (VAV1 Produits)
- Synonymes
- anticorps VAV, anticorps Vav, anticorps vav-T, anticorps vav guanine nucleotide exchange factor 1, anticorps vav 1 oncogene, anticorps vav guanine nucleotide exchange factor 1 L homeolog, anticorps VAV1, anticorps Vav1, anticorps vav1.L
- Sujet
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This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: VAV
Protein Interaction Partner: UBC, CD28, ERBB3, ERBB2, EGFR, PTPN22, SPI1, PLCG1, Mbp, CD5, PDGFRB, NOTCH1, FGFR1, DOK1, TUBB, SH3BP2, CBLB, CBL, FYN, SYK, LCP2, CD19, SOCS1, KHDRBS1, LMNA, TUBA1A, PHAX, ZAP70, ZNF655, DOCK2, XRCC5, PAG1, RACGAP1, MERTK, BLNK, NEK3, AOC3, ARHGDIB, DNM
Protein Size: 845 - Poids moléculaire
- 98 kDa
- ID gène
- 7409
- NCBI Accession
- NM_005428, NP_005419
- UniProt
- P15498
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling
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