BBS5 anticorps (Center)
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- Antigène Voir toutes BBS5 Anticorps
- BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
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Épitope
- AA 108-141, Center
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BBS5 est non-conjugé
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Application
- Western Blotting (WB)
- Fonction
- Rabbit Anti-Human BBS5 (Center) Antibody
- Immunogène
- This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product BBS5 Anticorps primaire
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- Indications d'application
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Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of lysate from K562 cell line, using BBS5 Antibody (Center) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 μg. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C (short-term), -20°C (long-term)
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- Antigène
- BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
- Autre désignation
- BBS5 (BBS5 Produits)
- Synonymes
- anticorps zgc:56578, anticorps 1700049I01Rik, anticorps 2700023J09Rik, anticorps Bardet-Biedl syndrome 5, anticorps Bardet-Biedl syndrome 5 (human), anticorps bbs5, anticorps BBS5, anticorps Bbs5
- Sujet
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Target Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Gene Symbol: BBS5
- Poids moléculaire
- 38755 Da
- ID gène
- 129880
- UniProt
- Q8N3I7
- Pathways
- Signalisation Hedgehog
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