CDKN2A anticorps (C-Term)
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- Antigène Voir toutes CDKN2A Anticorps
- CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
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Épitope
- AA 104-131, C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CDKN2A est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Fonction
- Rabbit Anti-Human p16INK4a (C-term E119) Antibody
- Immunogène
- This p16INK4a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-131 amino acids from the C-terminal region of human p16INK4a.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CDKN2A Anticorps primaire
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- Indications d'application
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Western Blot, Immunohistochemistry, Flow Cytometry, Immunofluorescence
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50, IF: 1:10-50Western blot analysis of lysate from A2058 cell line, using p16INK4a Antibody (C-term E119) . - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.270 mg/mL
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C (short-term), -20°C (long-term)
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- Antigène
- CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
- Autre désignation
- p16INK4a (CDKN2A Produits)
- Synonymes
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anticorps Arf, anticorps p16, anticorps MTS1, anticorps INK4A, anticorps p19ARF, anticorps p16Cdkn2a, anticorps ARF, anticorps CDK4I, anticorps CDKN2, anticorps CMM2, anticorps INK4, anticorps MLM, anticorps MTS-1, anticorps P14, anticorps P14ARF, anticorps P16, anticorps P16-INK4A, anticorps P16INK4, anticorps P16INK4A, anticorps P19, anticorps P19ARF, anticorps TP16, anticorps ARF-INK4a, anticorps INK4a-ARF, anticorps Ink4a/Arf, anticorps Pctr1, anticorps p16(INK4a), anticorps p16INK4a, anticorps p19
, anticorps cyclin-dependent kinase inhibitor 2A, anticorps cyclin dependent kinase inhibitor 2A, anticorps Cdkn2a, anticorps LOC100731972, anticorps LOC100340625, anticorps CDKN2A - Sujet
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Target Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Gene Symbol: CDKN2A
- Poids moléculaire
- 16533 Da
- ID gène
- 1029
- UniProt
- P42771
- Pathways
- Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus
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