PAFAH1B1 anticorps (AA 311-410) (AbBy Fluor® 594)
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- Antigène Voir toutes PAFAH1B1 Anticorps
- PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))
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Épitope
- AA 311-410
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Reactivité
- Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PAFAH1B1 est conjugé à/à la AbBy Fluor® 594
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris, Rat
- Homologie
- Human
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human LIS1
- Isotype
- IgG
- Top Product
- Discover our top product PAFAH1B1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))
- Autre désignation
- LIS1 (PAFAH1B1 Produits)
- Synonymes
- anticorps LIS1, anticorps LIS2, anticorps MDCR, anticorps MDS, anticorps PAFAH, anticorps LIS-1, anticorps Lis1, anticorps MMS10-U, anticorps Mdsh, anticorps Ms10u, anticorps Pafaha, anticorps lis2, anticorps mdcr, anticorps mds, anticorps pafah, anticorps pafah1b1-b, anticorps PAFAHA, anticorps Lis1a, anticorps platelet activating factor acetylhydrolase 1b regulatory subunit 1, anticorps platelet-activating factor acetylhydrolase, isoform 1b, subunit 1, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1, anticorps platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b, anticorps PAFAH1B1, anticorps Pafah1b1, anticorps pafah1b1.L, anticorps pafah1b1a, anticorps pafah1b1b
- Sujet
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Synonyms: MDS, LIS1, LIS2, MDCR, PAFAH, Platelet-activating factor acetylhydrolase IB subunit alpha, Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha, PAFAH1B1, PAFAHA
Background: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
- ID gène
- 5048
- UniProt
- P43034
- Pathways
- M Phase, Regulation of Cell Size
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