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MMP26 anticorps (AA 185-261) (AbBy Fluor® 594)

MMP26 Reactivité: Humain WB, IF (p), IF (cc) Hôte: Lapin Polyclonal AbBy Fluor® 594
N° du produit ABIN2804241
  • Antigène Voir toutes MMP26 Anticorps
    MMP26 (Matrix Metallopeptidase 26 (MMP26))
    Épitope
    • 14
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 185-261
    Reactivité
    • 38
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 33
    • 5
    Lapin
    Clonalité
    • 33
    • 5
    Polyclonal
    Conjugué
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MMP26 est conjugé à/à la AbBy Fluor® 594
    Application
    • 32
    • 14
    • 12
    • 12
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MMP26 intermedial
    Isotype
    IgG
    Top Product
    Discover our top product MMP26 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MMP26 (Matrix Metallopeptidase 26 (MMP26))
    Autre désignation
    MMP-26 (MMP26 Produits)
    Synonymes
    anticorps matrix metallopeptidase 26, anticorps MMP26
    Sujet

    Synonyms: MMP26_HUMAN, Endometase, Matrilysin 2, MMP26, Matrix Metalloproteinase 26, MMP 26.

    Background: Matrix metalloproteinase 26 preprotein, gelatinase A, 70kD type IV collagenase, gelatinase neutrophil. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26 degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26, also known as Matrilysin 2, was first cloned from human fetal cells, and identified as an MMP most closely related to MMP7 (Matrilysin 1). The homology between MMP7 and MMP26 is low (only 38 % identical), thus the functions are unlikely to be similar. Homology is much higher (48 % identical) for the comparable region of MMP12, but MMP26 appears to have broader substrate specificity than does MMP12. MMP26, like MMP7, lacks the hemopexin domain common to the other MMPs, but contains a Propeptide domain, cysteine switch activation site, followed by a catalytic domain, and a short vestige of the hinge region. MMP26 is apparently not glycosylated, and is a secreted MMP. Tissue analysis shows MMP26 most strongly in placenta and uterus, but also in kidney cells, lung cells, lymphocytes and lung or endometrial carcinoma cells. MMP26 is proteolytically active, cleaving casein in zymograms, and gelatin, a1PI, fibrinogen, fibronectin, vitronectin, type IV collagen, and apparently activating MMP9.

    ID gène
    56547
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