STRAP anticorps (AA 51-150) (AbBy Fluor® 594)
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- Antigène Voir toutes STRAP Anticorps
- STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))
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Épitope
- AA 51-150
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp STRAP est conjugé à/à la AbBy Fluor® 594
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Unrip
- Isotype
- IgG
- Top Product
- Discover our top product STRAP Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))
- Autre désignation
- Unrip (STRAP Produits)
- Synonymes
- anticorps MAWD, anticorps PT-WD, anticorps UNRIP, anticorps zgc:56677, anticorps zgc:77604, anticorps mawd, anticorps pt-wd, anticorps unrip, anticorps AW557906, anticorps C78091, anticorps C79202, anticorps Unrip, anticorps serine/threonine kinase receptor associated protein, anticorps tetratricopeptide repeat domain 5, anticorps serine/threonine kinase receptor associated protein L homeolog, anticorps serine/threonine kinase receptor associated protein S homeolog, anticorps STRAP, anticorps TTC5, anticorps strap, anticorps strap.L, anticorps strap.S, anticorps Strap
- Sujet
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Synonyms: MAP activator with WD repeats, MAWD, PTWD, serine/threonine kinase receptor associated protein, STRAP, UNR-interacting protein, UNRIP, WD 40 repeat protein PT WD, STRAP_HUMAN.
Background: Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
- ID gène
- 11171
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