EYA1 anticorps (AA 231-330) (Biotin)

N° du produit ABIN2808195

Détail du produit anti-EYA1 anticorps (Biotin)

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Épitope: AA 231-330

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA1 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EYA1

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur EYA1

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Autre désignation: EYA1 (EYA1 Produits)

Synonymes: anticorps EYA1, anticorps bop, anticorps bor, anticorps XEya1, anticorps wu:fc13c10, anticorps zgc:100770, anticorps BOP, anticorps BOR, anticorps BOS1, anticorps EYA transcriptional coactivator and phosphatase 1, anticorps EYA transcriptional coactivator and phosphatase 1 L homeolog, anticorps EYA1, anticorps eya1, anticorps Eya1, anticorps eya1.L

Sujet:

Synonyms: BOP, BOR, BOS1, OFC1, Eyes absent homolog 1, EYA1

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2.

ID gène: 2138

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus