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DMC1 anticorps (AA 251-340) (AbBy Fluor® 594)

DMC1 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 594
N° du produit ABIN2812416
  • Antigène Voir toutes DMC1 Anticorps
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Épitope
    • 15
    • 14
    • 9
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-340
    Reactivité
    • 56
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 8
    Lapin
    Clonalité
    • 49
    • 7
    Polyclonal
    Conjugué
    • 29
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DMC1 est conjugé à/à la AbBy Fluor® 594
    Application
    • 49
    • 29
    • 21
    • 14
    • 12
    • 12
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DMC1
    Isotype
    IgG
    Top Product
    Discover our top product DMC1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Autre désignation
    DMC1 (DMC1 Produits)
    Synonymes
    anticorps DMC1, anticorps zgc:136628, anticorps Dmc1h, anticorps Lim15, anticorps Mei11, anticorps sgdp, anticorps DCM1, anticorps DMC1H, anticorps LIM15, anticorps dJ199H16.1, anticorps DNA meiotic recombinase 1, anticorps DMC1, anticorps dmc1, anticorps Dmc1
    Sujet

    Synonyms: disrupted meiotic cDNA 1 homolog, dJ199H16.1, DMC 1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specic homologous recombination yeast, DMC1 homologue, DMC1H, HsLim15, LIM15, Meiotic recombination protein DMC1/LIM15 homolog, MGC150472, MGC150473, DMC1_HUMAN.

    Background: DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.

    ID gène
    11144
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