GCS1 anticorps (AA 51-150) (AbBy Fluor® 594)

N° du produit ABIN2813653

Détail du produit anti-GCS1 anticorps (AbBy Fluor® 594)

Antigène: GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))

Épitope: AA 51-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GCS1 est conjugé à/à la AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GCS1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GCS1

Antigène: GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))

Autre désignation: GCS1 (MOGS Produits)

Synonymes: anticorps Afu6g04210, anticorps AO090701000141, anticorps Mogs, anticorps CDG2B, anticorps CWH41, anticorps DER7, anticorps GCS1, anticorps 1810017N02Rik, anticorps AI181835, anticorps Gcs1, anticorps gcs1, anticorps im:7160827, anticorps wu:fe50a12, anticorps wu:fk09a10, anticorps zgc:158312, anticorps mannosyl-oligosaccharide glucosidase, anticorps mannosyl-oligosaccharide glucosidase GCS1, anticorps mannosyl-oligosaccharide glucosidase L homeolog, anticorps mannosyl oligosaccharide glucosidase, anticorps glucosidase 1, anticorps AFUA_6G04210, anticorps Tc00.1047053511015.10, anticorps Tc00.1047053511805.10, anticorps LOC5576381, anticorps AOR_1_260114, anticorps MGYG_00305, anticorps TERG_01248, anticorps mogs.L, anticorps TTHERM_00636930, anticorps LOAG_03690, anticorps Gcs1, anticorps MOGS, anticorps Mogs, anticorps mogs

Sujet:

Synonyms: EC 3.2.1.106, glucosidase I, Mannosyl oligosaccharide glucosidase, Mannosyl-oligosaccharide glucosidase, Mogs, MOGS_HUMAN, Processing A glucosidase I, Processing A-glucosidase I.

Background: Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER). Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway. It specifically removes the distal alpha 1,2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor. Glucosidase I contains a short cytosolic tail, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER. Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), which is characterized by generalized hypotonia, dysmorphic features, hepatomegaly, hypoventilation, feeding problems, seizures and death. Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, namely Arg486Thr and Phe652Leu, that affect polypeptide folding and active site formation.

ID gène: 7841

Pathways: SARS-CoV-2 Protein Interactome