Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y754 of human PDGFRA.
Homologie
Mouse (Murine),Rat (Rattus)
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 732-761 AA from human PDGFRA.
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Synonyms: PDGF-R-alpha, CD140a antigen, Alpha platelet-derived growth factor receptor