NOTCH2 anticorps (C-Term)

N° du produit ABIN2854343

Détail du produit anti-NOTCH2 anticorps

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTCH2 est non-conjugé

Application: Western Blotting (WB), ChIP DNA-Sequencing (ChIP-seq)

Réactivité croisée: Rat (Rattus)

Réactivité croisée (Details): Rat (89 %)

Attributs du produit: Rabbit polyclonal antibody to NOTCH2 (Notch homolog 2 (Drosophila))
NOTCH2 antibody [C2], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human NOTCH2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference Western blot 1:500-1:3000* ChIP-sequencing Assay-dependent dilution Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000* ChIP-sequencingAssay-dependent dilution

Commentaires:

Positive Control: A431 , HeLa , HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS, 40 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-NOTCH2 (ABIN2854343)

Lin, Xie, Lin, Fu, Su, Tong, Chen, Wang, Zhao, Xia, Zhang, Zhang: "Epistatic Association of CD14 and NOTCH2 Genetic Polymorphisms with Biliary Atresia in a Southern Chinese Population." dans: Molecular therapy. Nucleic acids, Vol. 13, pp. 590-595, (2018) (PubMed).

Détails sur NOTCH2

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Autre désignation: NOTCH2 (NOTCH2 Produits)

Synonymes: anticorps AGS2, anticorps HJCYS, anticorps hN2, anticorps AI853703, anticorps N2, anticorps notch6, anticorps sb:cb884, anticorps neurogenic locus notch homolog protein 2, anticorps notch 2, anticorps notch 3, anticorps LOC581186, anticorps NOTCH2, anticorps notch3, anticorps Notch2, anticorps notch2

Sujet: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

Cellular Localization: Cell membrane, Single-pass type I membrane protein , Notch 2 intracellular domain: Nucleus

Poids moléculaire: 265 kDa

ID gène: 4853

Pathways: Signalisation Notch, Stem Cell Maintenance