RAP1A anticorps (Center)

N° du produit ABIN2854404

Détail du produit anti-RAP1A anticorps

Antigène: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAP1A est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat (Rattus), Macaque rhésus, Boeuf (Vache)

Réactivité croisée (Details): Mouse (100 %), Rat (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Attributs du produit: Rabbit polyclonal antibody to RAP1A (RAP1A, member of RAS oncogene family)
RAP1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human RAP1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Commentaires:

Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.53 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-RAP1A (ABIN2854404)

Chinigò, Grolez, Audero, Bokhobza, Bernardini, Cicero, Toillon, Bailleul, Visentin, Ruffinatti, Brysbaert, Lensink, De Ruyck, Cantelmo, Fiorio Pla, Gkika: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." dans: Cancers, Vol. 14, Issue 9, (2022) (PubMed).

Détails sur RAP1A

Antigène: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Autre désignation: RAP1 (RAP1A Produits)

Synonymes: anticorps KREV-1, anticorps KREV1, anticorps RAP1, anticorps SMGP21, anticorps AI848598, anticorps G-22K, anticorps Krev-1, anticorps Rap1, anticorps RAP-1A, anticorps rap 1A, anticorps wu:fc66g06, anticorps zgc:86676, anticorps krev-1, anticorps krev1, anticorps rap1, anticorps RAP1A, member of RAS oncogene family, anticorps RAS-related protein 1a, anticorps RAP1A, member of RAS oncogene family a, anticorps RAP1A, member of RAS oncogene family L homeolog, anticorps RAP1A, anticorps Rap1a, anticorps rap1aa, anticorps rap1a.L

Sujet: The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50 % amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

Cellular Localization: Cell membrane, Lipid-anchor

Poids moléculaire: 21 kDa

ID gène: 5906

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor