Aconitase 1 anticorps

N° du produit ABIN2854415

Détail du produit anti-Aconitase 1 anticorps

Antigène: Aconitase 1 (ACO1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aconitase 1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)
Aconitase 1 antibody [N1C1]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431 , HeLa , HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.78 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Aconitase 1

Antigène: Aconitase 1 (ACO1)

Autre désignation: aconitase 1 (ACO1 Produits)

Synonymes: anticorps ACONS, anticorps IREB1, anticorps IREBP, anticorps IREBP1, anticorps IRP1, anticorps Acon1, anticorps Ratireb, anticorps ratireb, anticorps Aco1, anticorps AI256519, anticorps Aco-1, anticorps Irebp, anticorps Irp1, anticorps aconitase 1, anticorps aconitase 1, soluble, anticorps aconitase 1 L homeolog, anticorps ACO1, anticorps Aco1, anticorps aco1.L

Sujet: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Cellular Localization: Cytoplasm

Poids moléculaire: 98 kDa

ID gène: 48

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis