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PLAU anticorps

PLAU Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2854759
  • Antigène Voir toutes PLAU Anticorps
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    Reactivité
    • 81
    • 25
    • 19
    • 4
    • 3
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 72
    • 13
    • 12
    • 6
    Lapin
    Clonalité
    • 78
    • 22
    • 1
    Polyclonal
    Conjugué
    • 58
    • 14
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp PLAU est non-conjugé
    Application
    • 68
    • 56
    • 31
    • 15
    • 12
    • 11
    • 10
    • 9
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Humain
    Attributs du produit
    Rabbit Polyclonal antibody to Urokinase (plasminogen activator, urokinase)
    Urokinase antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human Urokinase. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product PLAU Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: H1299 , HCT116 , PC3 conditioned medium

    Validation: Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.4 mg/mL
    Buffer
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    Autre désignation
    plasminogen activator, urokinase (PLAU Produits)
    Synonymes
    anticorps PLAU, anticorps u-PA, anticorps ATF, anticorps BDPLT5, anticorps QPD, anticorps UPA, anticorps URK, anticorps uPA, anticorps UPAM, anticorps plasminogen activator, urokinase, anticorps urokinase-type plasminogen activator, anticorps PLAU, anticorps CpipJ_CPIJ002131, anticorps CpipJ_CPIJ006543, anticorps CpipJ_CPIJ013396, anticorps CpipJ_CPIJ013623, anticorps Plau
    Sujet
    This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Cellular Localization: Secreted
    Poids moléculaire
    49 kDa
    ID gène
    5328
    UniProt
    P00749
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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