Lamin A/C anticorps

N° du produit ABIN2854943

Détail du produit anti-Lamin A/C anticorps

Antigène: Lamin A/C (LMNA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to Lamin A + C
Lamin A + C antibody

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the center region of human Lamin A + C. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: NIH-3T3

Validation: Comparison, KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.73 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-Lamin A/C (ABIN2854943)

Zhang, Li, Guan, Zhou, Wang, Yang, Zhen, Dai, Zhao, Jiang, Xu: "MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation." dans: Frontiers in physiology, Vol. 11, pp. 510, (2020) (PubMed).

Kuo, Ling, Chiang, Chung, Lee, Chu, Wu, Chen, Lai, Tsai, Cheng, Lin: "Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit." dans: Theranostics, Vol. 9, Issue 9, pp. 2526-2540, (2020) (PubMed).

Bueno, Martínez-Morga, Martínez: "Non-proliferative neurogenesis in human periodontal ligament stem cells." dans: Scientific reports, Vol. 9, Issue 1, pp. 18038, (2019) (PubMed).

Wu, Yen, Kou, Wu: "Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0130599, (2016) (PubMed).

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: lamin A/C (LMNA Produits)

Synonymes: anticorps CDCD1, anticorps CDDC, anticorps CMD1A, anticorps CMT2B1, anticorps EMD2, anticorps FPL, anticorps FPLD, anticorps FPLD2, anticorps HGPS, anticorps IDC, anticorps LDP1, anticorps LFP, anticorps LGMD1B, anticorps LMN1, anticorps LMNC, anticorps LMNL1, anticorps PRO1, anticorps Dhe, anticorps 2459, anticorps 74/76, anticorps CG6944, anticorps D5, anticorps DM[[O]], anticorps Dm, anticorps Dm(0), anticorps Dm0, anticorps Dm1, anticorps Dm2, anticorps DmLamin, anticorps DmO, anticorps Dm[[0]], anticorps Dm[[1]], anticorps Dm[[2]], anticorps Dm[[mit]], anticorps Dm[[o]], anticorps Dmel\\CG6944, anticorps Dmo, anticorps LAM, anticorps Lam Dm[[0]], anticorps Lam(Dm0), anticorps LamDm[[0]], anticorps LamDm[[o]], anticorps Lam[[Dm0]], anticorps Lamin Dm[[0]], anticorps jf27, anticorps l(2)04643, anticorps l(2)25Ec, anticorps l(2)gdh-7, anticorps l(2)gdh7, anticorps l(2)jf27, anticorps lam, anticorps lamDm0, anticorps lamDm[[0]], anticorps lamin, anticorps lamin Dm0, anticorps lamin Dm[[0]], anticorps misg, anticorps nlam, anticorps cb948, anticorps fk66d12, anticorps wu:fk66d12, anticorps lmna-A, anticorps fpl, anticorps idc, anticorps lfp, anticorps cddc, anticorps emd2, anticorps fpld, anticorps hgps, anticorps ldp1, anticorps lmn1, anticorps lmnc, anticorps pro1, anticorps cdcd1, anticorps cmd1a, anticorps cmt2b1, anticorps lgmd1b, anticorps Lamin-A, anticorps lamin-L(III)-like, anticorps lamin A/C, anticorps lamin A, anticorps Lamin, anticorps lamin A/C L homeolog, anticorps lamin-L(III)-like, anticorps LMNA, anticorps Lmna, anticorps Lam, anticorps lmna, anticorps lmna.L, anticorps LMINA

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Cellular Localization: Nucleus

Poids moléculaire: 74 kDa

ID gène: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus