FLNB anticorps (N-Term)

N° du produit ABIN2854971

Détail du produit anti-FLNB anticorps

Antigène: FLNB (Filamin B, beta (FLNB))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLNB est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to Filamin B (filamin B, beta)
Filamin B antibody [N1], N-term

Purification: Affinity purified by Protein A.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human Filamin B. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: U87-MG , NIH-3T3 , 293T , A431 , HeLa , HepG2

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 10 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-FLNB (ABIN2854971)

Artym, Swatkoski, Matsumoto, Campbell, Petrie, Dimitriadis, Li, Mueller, Bugge, Gucek, Yamada: "Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network." dans: The Journal of cell biology, Vol. 208, Issue 3, pp. 331-50, (2015) (PubMed).

Détails sur FLNB

Antigène: FLNB (Filamin B, beta (FLNB))

Autre désignation: filamin B (FLNB Produits)

Synonymes: anticorps ABP-278, anticorps ABP-280, anticorps AOI, anticorps FH1, anticorps FLN-B, anticorps FLN1L, anticorps LRS1, anticorps SCT, anticorps TABP, anticorps TAP, anticorps AL024016, anticorps filamin B, anticorps filamin, beta, anticorps FLNB, anticorps Flnb

Sujet: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome, and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Cellular Localization: Isoform 1: Cytoplasm , cell cortex , Cytoplasm , cytoskeleton , myofibril , sarcomere , Z-disk , Isoform 2: Cytoplasm , Isoform 3: Cytoplasm , Isoform 6: Cytoplasm

Poids moléculaire: 278 kDa

ID gène: 2317

UniProt: O75369

Pathways: Maintenance of Protein Location