Factor VII anticorps

N° du produit ABIN2854983

Détail du produit anti-Factor VII anticorps

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Factor VII est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))
Factor VII antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: NIH-3T3

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.32 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Factor VII

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Autre désignation: coagulation factor VII (F7 Produits)

Synonymes: anticorps F7, anticorps wu:fb59f04, anticorps zgc:109870, anticorps SPCA, anticorps AI114908, anticorps ATIII, anticorps At-3, anticorps At3, anticorps LOC100223776, anticorps AI132620, anticorps Cf7, anticorps FVII, anticorps mfVII, anticorps f7, anticorps coagulation factor VII, anticorps serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1, anticorps coagulation factor 7 (serum prothrombin conversion accelerator) S homeolog, anticorps F7, anticorps f7, anticorps Serpinc1, anticorps CpipJ_CPIJ009142, anticorps CpipJ_CPIJ010295, anticorps CpipJ_CPIJ020127, anticorps fa7, anticorps f7.S

Sujet: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.

Cellular Localization: Secreted

Poids moléculaire: 52 kDa

ID gène: 2155

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling