Lactate Dehydrogenase A anticorps

N° du produit ABIN2855034

Détail du produit anti-Lactate Dehydrogenase A anticorps

Antigène: Lactate Dehydrogenase A (LDHA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lactate Dehydrogenase A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to Lactate Dehydrogenase (lactate dehydrogenase A)
LDHA antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human LDHA. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: PC-12 , Rat2 , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , 293T , A431 , HeLa , HepG2

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.33 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-Lactate Dehydrogenase A (ABIN2855034)

Thompson, Alvarez, Singha, Pavesic, Nguyen, Nelson, Fruman, Razorenova: "Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism." dans: Molecular cancer therapeutics, Vol. 17, Issue 8, pp. 1781-1792, (2019) (PubMed).

Zera, Zastre: "Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes." dans: PLoS ONE, Vol. 12, Issue 10, pp. e0186707, (2017) (PubMed).

Ugun-Klusek, Tatham, Elkharaz, Constantin-Teodosiu, Lawler, Mohamed, Paine, Anderson, John Mayer, Lowe, Ellen Billett, Bedford: "Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway." dans: Cell death & disease, Vol. 8, Issue 1, pp. e2531, (2017) (PubMed).

Détails sur Lactate Dehydrogenase A

Antigène: Lactate Dehydrogenase A (LDHA)

Autre désignation: lactate dehydrogenase A (LDHA Produits)

Synonymes: anticorps GSD11, anticorps LDH1, anticorps LDHM, anticorps LDH-M, anticorps ldh-h, anticorps ldha, anticorps ldha-B, anticorps ldhbb, anticorps trg-5, anticorps Ldh1, anticorps Ldhm, anticorps l7R2, anticorps gsd11, anticorps ldh-m, anticorps ldh1, anticorps ldhm, anticorps pig19, anticorps ldha1, anticorps ldhab, anticorps LDH-A, anticorps LDHC, anticorps lactate dehydrogenase A, anticorps lactate dehydrogenase B L homeolog, anticorps lactate dehydrogenase A4, anticorps lactate dehydrogenase A L homeolog, anticorps L-lactate dehydrogenase A chain, anticorps LDHA, anticorps ldhb.L, anticorps Ldha, anticorps ldha, anticorps ldha.L, anticorps LOC100713875

Sujet: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Cellular Localization: Cytoplasm

Poids moléculaire: 37 kDa

ID gène: 3939

UniProt: P00338

Pathways: L'effet Warburg