alpha Adducin anticorps

N° du produit ABIN2855094

Détail du produit anti-alpha Adducin anticorps

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha Adducin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to alpha Adducin (adducin 1 (alpha))
alpha Adducin antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human alpha Adducin. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Jurkat , Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.81 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur alpha Adducin

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Autre désignation: adducin 1 (ADD1 Produits)

Synonymes: anticorps ADDA, anticorps AI256389, anticorps alpha-adducin, anticorps bZ1H20.1, anticorps cb787, anticorps zgc:158352, anticorps add2, anticorps adda, anticorps add1-a, anticorps ADD1, anticorps adducin 1, anticorps adducin 1 (alpha), anticorps adducin 1 S homeolog, anticorps ADD1, anticorps Add1, anticorps add1, anticorps add1.S

Sujet: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms, however, not all variants have been fully described.

Cellular Localization: Cytoplasm , cytoskeleton , Cell membrane

Poids moléculaire: 81 kDa

ID gène: 118

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling