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GRK2 anticorps (C-Term)

KO Validated ADRBK1 Reactivité: Humain WB, IHC (p), IF, ICC, FACS, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2855125
  • Antigène Voir toutes GRK2 (ADRBK1) Anticorps
    GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
    Épitope
    • 16
    • 11
    • 10
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 101
    • 80
    • 59
    • 9
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 94
    • 9
    • 2
    • 2
    Lapin
    Clonalité
    • 90
    • 17
    Polyclonal
    Conjugué
    • 61
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRK2 est non-conjugé
    Application
    • 58
    • 46
    • 34
    • 18
    • 14
    • 13
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Rabbit Polyclonal antibody to GRK2 (adrenergic, beta, receptor kinase 1)
    GRK2 antibody [C2C3], C-term
    Purification
    Purified by antigen-affinity chromatography.
    Classe de qualité
    KO Validated
    Immunogène
    Recombinant protein encompassing a sequence within the C-terminus region of human GRK2. The exact sequence is proprietary.
    Isotype
    IgG
  • Indications d'application
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: ADRBK1-transfected 293T

    Validation: KO/KD, Overexpression

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.82 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
    Autre désignation
    G protein-coupled receptor kinase 2 (ADRBK1 Produits)
    Synonymes
    anticorps Adrbk-1, anticorps Bark-1, anticorps GRK2, anticorps betaARK1, anticorps BARK1, anticorps BETA-ARK1, anticorps GRK-2, anticorps Grk2, anticorps beta-adrenergic receptor kinase 1, anticorps G protein-coupled receptor kinase 2, anticorps Tsp_00497, anticorps grk2, anticorps Grk2, anticorps GRK2
    Sujet
    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

    Poids moléculaire
    80 kDa
    ID gène
    156
    UniProt
    P25098
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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