CD44 anticorps

N° du produit ABIN2855292

Détail du produit anti-CD44 anticorps

Highlights:

• High quality CD44 Anticorps primaire for the detection of CD44.
• Reliable product with high standard validation data

Antigène: CD44

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD44 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Live Cell Imaging (LCI)

Specificité: IP/MS validation was supported by references (PMID:30377381)

Réactivité croisée: Humain, Lapin, Rat

Attributs du produit: Rabbit Polyclonal antibody to CD44 (CD44 Molecule (Indian blood group))
CD44 antibody

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the center region of human CD44. The exact sequence is proprietary.

Isotype: IgG

Informations sur le produit:

À quoi peut servir l'anticorps CD44 ABIN2855292 ? Cet anticorps polyclonal non conjugué de lapin anti-CD44 est excellent pour la détection de la protéine de surface CD44 en western blot, immunocytochimie, immunofluorescence et immunohistochimie. Il présente les réactivités souris, lapin, humain. Une protéine recombinante comprenant une séquence dans la région centrale de la molécule CD44 humaine a été utilisée comme immunogène.

Quelles sont les données de validation disponibles pour cet anticorps CD44 ? L'anticorps CD44 a été référencé dans 3 publications à ce jour, qui sont indiquées ci-dessous et peuvent être consultées sur Pubmed. Il existe 8 images de l'anticorps anti-CD44 de lapin montrant ses performances en Western blot, IHC et ICC / IF. Utilisez notre anticorps CD44 pour une détection fiable de la CD44.

Quelle est la fonction du CD44 ? Le CD44 est un récepteur de surface cellulaire qui joue un rôle dans les interactions cellule-cellule, l'adhésion et la migration des cellules, les aidant à sentir et à répondre aux changements du microenvironnement tissulaire. La molécule CD44 participe ainsi à une grande variété de fonctions cellulaires, notamment l'activation, la recirculation et le homing des lymphocytes T, l'hématopoïèse, l'inflammation et la réponse aux infections bactériennes. (UniProt)

Information d'application

Indications d'application: WB: 1:1000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: MDA-MB-231(24 μg/ml Tunicamycin treatment for 16 hr) , HeLa(12 μg/ml Tunicamycin treatment for 48 hr)

Validation: Comparison, IP/MS, KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-CD44 (ABIN2855292)

Li, Gao, Wang, Song, Xu, Xie, Zhou, Pan, Peng, Zhang, Ge, Zhong: "Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations." dans: Frontiers in molecular neuroscience, Vol. 12, pp. 212, (2019) (PubMed).

Sun, Wu, Sheu, Chang, Chen, Lin, Chuang, Hsu, Chang: "Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth." dans: Oncotarget, Vol. 7, Issue 34, pp. 55572-55584, (2018) (PubMed).

Jiang, Guo, Li, Yu, Zhou, Gong: "Combination Twist1 and CA15-3 in axillary lymph nodes for breast cancer prognosis." dans: Molecular medicine reports, Vol. 15, Issue 3, pp. 1123-1134, (2017) (PubMed).

Détails sur CD44

Antigène: CD44

Autre désignation: CD44 molecule (Indian blood group) (CD44 Produits)

Synonymes: anticorps CDW44, anticorps CSPG8, anticorps ECMR-III, anticorps HCELL, anticorps HUTCH-I, anticorps IN, anticorps LHR, anticorps MC56, anticorps MDU2, anticorps MDU3, anticorps MIC4, anticorps Pgp1, anticorps AU023126, anticorps AW121933, anticorps AW146109, anticorps HERMES, anticorps Ly-24, anticorps Pgp-1, anticorps CD44A, anticorps METAA, anticorps RHAMM, anticorps XCD44, anticorps cd44, anticorps cdw44, anticorps cspg8, anticorps ecmr-iii, anticorps hcell, anticorps lhr, anticorps mc56, anticorps mdu2, anticorps mdu3, anticorps mic4, anticorps mutch-i, anticorps pgp1, anticorps CD44 molecule (Indian blood group), anticorps syndecan 4, anticorps CD44 antigen, anticorps CD44 molecule (Indian blood group) S homeolog, anticorps CD44, anticorps SDC4, anticorps Cd44, anticorps cd44.S

Sujet: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Cellular Localization: Membrane

Poids moléculaire: 82 kDa

ID gène: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling