NLRC4 anticorps (N-Term)
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- Antigène Voir toutes NLRC4 Anticorps
- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NLRC4 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Humain
- Attributs du produit
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Rabbit Polyclonal antibody to CARD12 (NLR family, CARD domain containing 4)
CARD12 antibody [N1], N-term - Purification
- Purified by antigen-affinity chromatography.
- Immunogène
- Recombinant protein encompassing a sequence within the N-terminus region of human CARD12. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product NLRC4 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: MCF-7 , human NLRC4-transfected 293T cells
Validation: Overexpression
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Antigène
- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
- Autre désignation
- NLR family CARD domain containing 4 (NLRC4 Produits)
- Synonymes
- anticorps CARD12, anticorps CLAN, anticorps CLAN1, anticorps CLANA, anticorps CLANB, anticorps CLANC, anticorps CLAND, anticorps CLR2.1, anticorps IPAF, anticorps 9530011P19Rik, anticorps Card12, anticorps NLR family CARD domain containing 4, anticorps NLR family, CARD domain containing 4, anticorps NLRC4, anticorps Nlrc4
- Sujet
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In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]
Cellular Localization: Cytoplasm - Poids moléculaire
- 116 kDa
- ID gène
- 58484
- UniProt
- Q9NPP4
- Pathways
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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