Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (C-Term) anticorps

N° du produit ABIN2855378

Détail du produit

Antigène: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Réactivité croisée: Boeuf (Vache)

Réactivité croisée (Details): Bovine (95 %)

Attributs du produit: Rabbit polyclonal antibody to CBL-B (Cas-Br-M (murine) ecotropic retroviral transforming sequence b)
Cbl-b antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human Cbl-b. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Commentaires:

Positive Control: HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.72 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détail du antigène

Antigène: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Autre désignation: CBL-B (CBLB Produits)

Synonymes: anticorps rnf56, anticorps cblb, anticorps AI429560, anticorps AI851073, anticorps Cbl-b, anticorps Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog, anticorps Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog, anticorps Casitas B-lineage lymphoma b, anticorps Cbl proto-oncogene B, anticorps cblb.S, anticorps cblb.L, anticorps Cblb, anticorps CBLB

Sujet: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.

Cellular Localization: Cytoplasm

Poids moléculaire: 109 kDa

ID gène: 868