CARD8 anticorps (C-Term)

N° du produit ABIN2855381

Détail du produit anti-CARD8 anticorps

Antigène: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD8 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to CARD8 (caspase recruitment domain family, member 8)
CARD8 antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human CARD8. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431 , HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CARD8

Antigène: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Autre désignation: caspase recruitment domain family member 8 (CARD8 Produits)

Synonymes: anticorps CARD8, anticorps CARDINAL, anticorps DACAR, anticorps DAKAR, anticorps NDPP, anticorps NDPP1, anticorps TUCAN, anticorps caspase recruitment domain family, member 8, anticorps caspase recruitment domain-containing protein 8, anticorps caspase recruitment domain family member 8, anticorps CARD8, anticorps LOC718594

Sujet: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.

Cellular Localization: Cytoplasm , Nucleus

Poids moléculaire: 49 kDa

ID gène: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity