Cyclin A anticorps
-
- Antigène Voir toutes Cyclin A (CCNA2) Anticorps
- Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Cyclin A est non-conjugé
-
Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Specificité
- IP/MS validation was supported by references (PMID:30377384)
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
-
Rabbit Polyclonal antibody to Cyclin A2 (cyclin A2)
Cyclin A2 antibody - Purification
- Purified by antigen-affinity chromatography.
- Classe de qualité
- KO Validated
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human Cyclin A2. The exact sequence is proprietary.
- Isotype
- IgG
-
-
- Indications d'application
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
-
Positive Control: Neuro2A , PC-12 , IMR32 , SK-N-AS , HeLa(100 μg/ml Bleomycin treatment for 24 hr)
Validation: IP/MS, KO/KD, Orthogonal, Overexpression
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.73 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression." dans: Scientific reports, Vol. 10, Issue 1, pp. 1140, (2020) (PubMed).
: "Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity." dans: Oncotarget, Vol. 10, Issue 3, pp. 404-414, (2019) (PubMed).
: "Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes." dans: Molecular medicine reports, Vol. 17, Issue 3, pp. 4337-4344, (2018) (PubMed).
: "Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells." dans: PLoS ONE, Vol. 9, Issue 8, pp. e104203, (2015) (PubMed).
: "The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB." dans: Cancer cell international, Vol. 14, Issue 1, pp. 1, (2014) (PubMed).
: "
-
PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression." dans: Scientific reports, Vol. 10, Issue 1, pp. 1140, (2020) (PubMed).
-
- Antigène
- Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
- Autre désignation
- cyclin A2 (CCNA2 Produits)
- Synonymes
- anticorps CCN1, anticorps CCNA, anticorps AA408589, anticorps Ccn-1, anticorps Ccn1, anticorps Ccna, anticorps CycA2, anticorps Cyca, anticorps cb671, anticorps chunp6924, anticorps wu:fi36f03, anticorps CYCA, anticorps Cyclin-A2, anticorps ccna2, anticorps ccn1, anticorps ccna, anticorps ccna1, anticorps Cyclin-A, anticorps cyclinA, anticorps cyclin A2, anticorps cyclin A2 S homeolog, anticorps cyclin A2 L homeolog, anticorps CCNA2, anticorps Ccna2, anticorps ccna2, anticorps ccna2.S, anticorps ccna2.L
- Sujet
-
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Cellular Localization: Nucleus , Cytoplasm - Poids moléculaire
- 49 kDa
- ID gène
- 890
- UniProt
- P20248
- Pathways
- Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
-