Calpain 5 anticorps

N° du produit ABIN2855597

Détail du produit anti-Calpain 5 anticorps

Antigène: Calpain 5 (CAPN5)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calpain 5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit polyclonal antibody to Calpain-5 (calpain 5)
Calpain-5 antibody [N1C1]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Calpain 5. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: mouse uterus , RMS-13

Validation: Orthogonal, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.39 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-Calpain 5 (ABIN2855597)

Velez, Bassuk, Schaefer, Brooks, Gakhar, Mahajan, Kahn, Tsang, Ferguson, Mahajan: "A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay." dans: Cold Spring Harbor molecular case studies, Vol. 4, Issue 3, (2019) (PubMed).

Schaefer, Toral, Velez, Cox, Baker, Borcherding, Colgan, Bondada, Mashburn, Yu, Geddes, Tsang, Bassuk, Mahajan: "Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses." dans: Investigative ophthalmology & visual science, Vol. 57, Issue 6, pp. 2509-21, (2016) (PubMed).

Détails sur Calpain 5

Antigène: Calpain 5 (CAPN5)

Autre désignation: calpain 5 (CAPN5 Produits)

Synonymes: anticorps HTRA3, anticorps nCL-3, anticorps Htra3, anticorps capn5, anticorps MGC53448, anticorps MGC89353, anticorps CAPN5, anticorps zgc:153446, anticorps calpain 5, anticorps calpain 5 L homeolog, anticorps calpain 5a, anticorps calpain 6, anticorps CAPN5, anticorps Capn5, anticorps capn5.L, anticorps capn5, anticorps capn5a, anticorps Bm1_30735, anticorps Bm1_30740, anticorps CAPN6, anticorps LOAG_10085

Sujet: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

Poids moléculaire: 73 kDa

ID gène: 726

UniProt: O15484