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L3MBTL1 anticorps (Center)

L3MBTL1 Reactivité: Humain WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2855703
  • Antigène Voir toutes L3MBTL1 Anticorps
    L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))
    Épitope
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 18
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 17
    • 2
    • 1
    Lapin
    Clonalité
    • 18
    • 1
    • 1
    Polyclonal
    Conjugué
    • 19
    • 1
    Cet anticorp L3MBTL1 est non-conjugé
    Application
    • 14
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
     Réactivité croisée
    Souris
    Réactivité croisée (Details)
    mouse (88 %)
    Attributs du produit
    Rabbit polyclonal antibody to L3MBTL (l(3)mbt-like (Drosophila))
    L3MBTL antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human L3MBTL. The exact sequence is proprietary.
    Isotype
    IgG
  • Indications d'application
    Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*
    Commentaires

    Positive Control: HeLaS3 , human L3MBTL-transfected 293T

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Lu, Periz, Lu, Tang, Liu, Zhang, Shah, Thombre, Aljumaah, Li, Mojsilovic-Petrovic, Ji, Johnson, Kalb, Wang: "L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control." dans: Nature neuroscience, Vol. 22, Issue 6, pp. 875-886, (2019) (PubMed).

  • Antigène
    L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))
    Autre désignation
    L3MBTL (L3MBTL1 Produits)
    Synonymes
    anticorps C630004G01, anticorps L3mbtl, anticorps mKIAA0681, anticorps H-L(3)MBT, anticorps L3MBTL, anticorps ZC2HC3, anticorps dJ138B7.3, anticorps RGD1307316, anticorps l(3)mbt-like (Drosophila), anticorps L3MBTL1, histone methyl-lysine binding protein, anticorps l(3)mbt-like 1 (Drosophila), anticorps L3mbtl1, anticorps L3MBTL1
    Sujet
    This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

    Cellular Localization: Nucleus
    Poids moléculaire
    84 kDa
    ID gène
    26013
    Pathways
    Chromatin Binding
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