CDK6 anticorps

N° du produit ABIN2855743

Détail du produit anti-CDK6 anticorps

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to CDK6 (cyclin-dependent kinase 6)
CDK6 antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the center region of human CDK6. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validatio: KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-CDK6 (ABIN2855743)

Méndez-Barbero, Gutierrez-Muñoz, Madrigal-Matute, Mínguez, Egido, Michel, Martín-Ventura, Esteban, Blanco-Colio: "A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis." dans: EBioMedicine, Vol. 46, pp. 274-289, (2020) (PubMed).

Zhang, Liu, Li, Cao, Wan, Xi, Li, Tan, Wang, Wu, Ma, Gao: "Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer." dans: Journal of hematology & oncology, Vol. 10, Issue 1, pp. 29, (2017) (PubMed).

Détails sur CDK6

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Autre désignation: cyclin dependent kinase 6 (CDK6 Produits)

Synonymes: anticorps CDK6, anticorps PLSTIRE, anticorps 5830411I20, anticorps AI504062, anticorps Crk2, anticorps cyclin dependent kinase 6, anticorps cyclin-dependent kinase 6, anticorps CDK6, anticorps Cdk6

Sujet: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Poids moléculaire: 37 kDa

ID gène: 1021

UniProt: Q00534

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases