ETS2 anticorps (Center)

N° du produit ABIN2855845

Détail du produit anti-ETS2 anticorps

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Épitope: Center

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETS2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC)

Attributs du produit: Rabbit Polyclonal antibody to ETS2 (v-ets erythroblastosis virus E26 oncogene homolog 2 (avian))
ETS2 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human ETS2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*

Commentaires:

Positive Control: HeLa

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS, 1 % BSA, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-ETS2 (ABIN2855845)

Gluck, Glathar, Tsompana, Nowak, Garrett-Sinha, Buck, Sinha: "Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma." dans: PLoS genetics, Vol. 15, Issue 7, pp. e1008250, (2019) (PubMed).

Yuan, Jiang, Mayakonda, Huang, Ding, Lin, Yu, Lu, Loh, Chow, Savage, Tyner, Lin, Koeffler: "Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma." dans: Cancer research, Vol. 77, Issue 23, pp. 6614-6626, (2018) (PubMed).

Helbig, Wockner, Bouendeu, Hille-Betz, McCue, French, Edwards, Pickett, Reddel, Chenevix-Trench, Dörk, Beesley: "Functional dissection of breast cancer risk-associated TERT promoter variants." dans: Oncotarget, Vol. 8, Issue 40, pp. 67203-67217, (2017) (PubMed).

Détails sur ETS2

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Autre désignation: ETS2 (ETS2 Produits)

Synonymes: anticorps 0123/09, anticorps 0608/07, anticorps 0998/12, anticorps 3520, anticorps CG17077, anticorps CG8705, anticorps D-Ets-2, anticorps D-ets-2, anticorps DMPOINT1A, anticorps Dmel\\CG17077, anticorps E(E2F)3D, anticorps EK3-2, anticorps ETS2, anticorps EY3-1, anticorps Ets, anticorps Ets2, anticorps Ets58AB, anticorps Ets94F, anticorps PNT-P1, anticorps PNTP1, anticorps PNTP2, anticorps POINT, anticorps Pnt, anticorps Pnt-P1, anticorps PntP1, anticorps PntP2, anticorps Pointed-P1, anticorps ets94F, anticorps l(3)07825, anticorps l(3)j1B7, anticorps l(3)s118306, anticorps png, anticorps pnt-P1, anticorps pnt-P2, anticorps pntP2, anticorps pntegfr, anticorps pointed-RC, anticorps ptd, anticorps zgc:92106, anticorps wu:fe02h08, anticorps wu:fk74c05, anticorps AU022856, anticorps Ets-2, anticorps ETS2IT1, anticorps c-ets-2, anticorps pointed, anticorps v-ets avian erythroblastosis virus E26 oncogene homolog 2, anticorps E26 avian leukemia oncogene 2, 3' domain, anticorps ETS proto-oncogene 2, transcription factor, anticorps pnt, anticorps ets2, anticorps Ets2, anticorps ETS2

Sujet: ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]

Cellular Localization: Nucleus

Poids moléculaire: 53 kDa

ID gène: 2114

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction