GNAQ anticorps (Center)

N° du produit ABIN2855848

Détail du produit anti-GNAQ anticorps

Antigène: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNAQ est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Chien, Porc, Boeuf (Vache), Macaque rhésus

Réactivité croisée (Details): Dog (100 %), Pig (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Attributs du produit: Rabbit polyclonal antibody to GNAQ (guanine nucleotide binding protein (G protein), q polypeptide)
GNAQ antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human GNAQ. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Commentaires:

Positive Control: 3xFlag-human GNAQ-transfected 293T

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-GNAQ (ABIN2855848)

Rushton, Korb, Kummer, Reichart, Fuchs-Baumgartinger, Tichy, Nell: "Protein expression of KIT, BRAF, GNA11, GNAQ and RASSF1 in feline diffuse iris melanomas." dans: Veterinary journal (London, England : 1997), Vol. 249, pp. 33-40, (2019) (PubMed).

Détails sur GNAQ

Antigène: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Autre désignation: GNAQ (GNAQ Produits)

Synonymes: anticorps si:ch73-270f14.2, anticorps CMC1, anticorps G-ALPHA-q, anticorps GAQ, anticorps SWS, anticorps Galphaq, anticorps Gnaq, anticorps g-alpha-q, anticorps gaq, anticorps gnaqb, anticorps 1110005L02Rik, anticorps 6230401I02Rik, anticorps AA408290, anticorps AW060788, anticorps Dsk1, anticorps Dsk10, anticorps Gq, anticorps GqI, anticorps guanine nucleotide binding protein (G protein), q polypeptide, anticorps G protein subunit alpha q, anticorps guanine nucleotide binding protein (G protein), q polypeptide S homeolog, anticorps guanine nucleotide binding protein, alpha q polypeptide, anticorps gnaq, anticorps GNAQ, anticorps Gnaq, anticorps gnaq.S

Sujet: Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]

Poids moléculaire: 42 kDa

ID gène: 2776

Pathways: Signalistation JAK/STAT, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction