HSD11B1 anticorps (C-Term)

N° du produit ABIN2855871

Détail du produit anti-HSD11B1 anticorps

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Mouton

Attributs du produit: Rabbit Polyclonal antibody to HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)
HSD11B1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human HSD11B1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-HSD11B1 (ABIN2855871)

Matsumura, Terao, Itami, Katayama: "Local cortisol activation is involved in EGF-induced immunosuppression." dans: Dermato-endocrinology, Vol. 9, Issue 1, pp. e1412018, (2017) (PubMed).

Détails sur HSD11B1

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Autre désignation: hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1 Produits)

Synonymes: anticorps 11-DH, anticorps 11-beta-HSD1, anticorps CORTRD2, anticorps HDL, anticorps HSD11, anticorps HSD11B, anticorps HSD11L, anticorps SDR26C1, anticorps hsd11, anticorps hsd11b, anticorps LRRGT00065, anticorps hydroxysteroid 11-beta dehydrogenase 1, anticorps hydroxysteroid (11-beta) dehydrogenase 1b, anticorps hydroxysteroid (11-beta) dehydrogenase 1 L homeolog, anticorps HSD11B1, anticorps HSD11B1b, anticorps hsd11b1.L, anticorps Hsd11b1

Sujet: The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Cellular Localization: Endoplasmic reticulum membrane

Poids moléculaire: 32 kDa

ID gène: 3290

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process