Dystroglycan anticorps

N° du produit ABIN2856020

Détail du produit anti-Dystroglycan anticorps

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dystroglycan est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Réactivité croisée: Cheval, Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to alpha Dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1))
DAG1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human DAG1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: U87-MG membrane fraction extract , MCF-7 membrane extracts , 293T membrane extracts

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.21 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-Dystroglycan (ABIN2856020)

Jae, Raaben, Herbert, Kuehne, Wirchnianski, Soh, Stubbs, Janssen, Damme, Saftig, Whelan, Dye, Brummelkamp: "Virus entry. Lassa virus entry requires a trigger-induced receptor switch." dans: Science (New York, N.Y.), Vol. 344, Issue 6191, pp. 1506-10, (2014) (PubMed).

Détails sur Dystroglycan

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Autre désignation: dystroglycan 1 (DAG1 Produits)

Synonymes: anticorps LOC398500, anticorps dag1, anticorps MGC53537, anticorps 156DAG, anticorps A3a, anticorps AGRNR, anticorps DAG, anticorps MDDGC7, anticorps MDDGC9, anticorps DAG1, anticorps RAB7, anticorps dg, anticorps a3a, anticorps dag, anticorps agrnr, anticorps 156dag, anticorps D9Wsu13e, anticorps DG, anticorps Dp427, anticorps Dp71, anticorps CG18250, anticorps CT41273, anticorps DmDG, anticorps Dmel\\CG18250, anticorps atu, anticorps dgn, anticorps dys, anticorps GB14967, anticorps APOJ, anticorps CLI, anticorps RATTRPM2B, anticorps SGP-2, anticorps SGP2, anticorps SP-40, anticorps SP40, anticorps TRPM-2, anticorps TRPM2B, anticorps Trpm2, anticorps Trpmb, anticorps Ala-1, anticorps H9/25, anticorps Ly-27, anticorps Ly-6, anticorps Ly27, anticorps wu:fb83d06, anticorps wu:fi25f06, anticorps wu:fi37b08, anticorps zgc:109786, anticorps DystroGlycaN, anticorps dystroglycan 1 L homeolog, anticorps dystroglycan 1, anticorps dystroglycan 1 S homeolog, anticorps Dystroglycan, anticorps dystroglycan, anticorps clusterin, anticorps lymphocyte antigen 6 complex, anticorps dgn-1, anticorps dag1.L, anticorps dgn-2, anticorps dgn-3, anticorps DAG1, anticorps dag1.S, anticorps Dag1, anticorps dag1, anticorps Dg, anticorps LOC408826, anticorps Clu, anticorps Ly6

Sujet: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.

Cellular Localization: Alpha-dystroglycan: Secreted , extracellular space , Beta-dystroglycan: Cell membrane , Cytoplasm , cytoskeleton

Poids moléculaire: 97 kDa

ID gène: 1605

UniProt: Q14118

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus