BCL2L1 anticorps
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- Antigène Voir toutes BCL2L1 Anticorps
- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BCL2L1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Réactivité croisée
- Chien, Humain, Souris, Rat
- Attributs du produit
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Rabbit Polyclonal antibody to Bcl-X (BCL2-like 1)
Bcl-X antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human Bcl-X. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product BCL2L1 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: NIH-3T3 , PC-12
Validation: Orthogonal
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.45 mg/mL
- Buffer
- 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction." dans: FEBS letters, Vol. 589, Issue 23, pp. 3581-7, (2016) (PubMed).
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Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction." dans: FEBS letters, Vol. 589, Issue 23, pp. 3581-7, (2016) (PubMed).
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- Antigène
- BCL2L1 (BCL2-Like 1 (BCL2L1))
- Autre désignation
- BCL2 like 1 (BCL2L1 Produits)
- Synonymes
- anticorps BCL-XL/S, anticorps BCL2L, anticorps BCLX, anticorps BCLXL, anticorps BCLXS, anticorps Bcl-X, anticorps PPP1R52, anticorps bcl-xL, anticorps bcl-xS, anticorps Bcl(X)L, anticorps Bcl-XL, anticorps Bcl-Xs, anticorps Bcl2l, anticorps BclX, anticorps bcl-x, anticorps Bcl-xl, anticorps Bclx, anticorps bcl-X, anticorps Bcl-xL, anticorps BCL-XL, anticorps BCL2L1, anticorps bcl-XL, anticorps bcl-x(l), anticorps bcl-xl/s, anticorps bcl-xs, anticorps bcl2l, anticorps bclx, anticorps bclxl, anticorps xR11, anticorps bcl-xl, anticorps blp1, anticorps cb1021, anticorps zfBLP1, anticorps BCL2 like 1, anticorps BCL2-like 1, anticorps Bcl2-like 1, anticorps BCL2-like 1 L homeolog, anticorps bcl2-like 1, anticorps BCL2L1, anticorps Bcl2l1, anticorps bcl2l1, anticorps bcl2l1.L
- Sujet
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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Cellular Localization: Mitochondrion membrane, Single-pass membrane protein , Nucleus membrane, Single-pass membrane protein, Cytoplasmic side , Mitochondrion membrane , Nucleus membrane - Poids moléculaire
- 26 kDa
- ID gène
- 598
- UniProt
- Q07817
- Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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