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SIGLEC7 anticorps

SIGLEC7 Reactivité: Humain WB, IHC (p), ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2856478
  • Antigène Voir toutes SIGLEC7 Anticorps
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Reactivité
    • 86
    • 11
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 62
    • 24
    Lapin
    Clonalité
    • 62
    • 23
    • 1
    Polyclonal
    Conjugué
    • 37
    • 12
    • 10
    • 9
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIGLEC7 est non-conjugé
    Application
    • 63
    • 45
    • 40
    • 17
    • 8
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)
     Réactivité croisée
    Humain
    Attributs du produit
    Rabbit Polyclonal antibody to Siglec 7 (sialic acid binding Ig-like lectin 7)
    Siglec 7 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human Siglec 7. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product SIGLEC7 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: K562 , THP-1 , HL-60 , NCI-H929

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Autre désignation
    sialic acid binding Ig like lectin 7 (SIGLEC7 Produits)
    Synonymes
    anticorps SIGLEC7, anticorps AIRM1, anticorps CD328, anticorps CDw328, anticorps D-siglec, anticorps QA79, anticorps SIGLEC-7, anticorps SIGLEC19P, anticorps SIGLECP2, anticorps p75, anticorps p75/AIRM1, anticorps sialic acid-binding Ig-like lectin 7, anticorps sialic acid binding Ig like lectin 7, anticorps LOC468976, anticorps SIGLEC7
    Sujet
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

    Cellular Localization: Membrane, Single-pass type I membrane protein
    Poids moléculaire
    51 kDa
    ID gène
    27036
    UniProt
    Q9Y286
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