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LIMK2 anticorps

LIMK2 Reactivité: Humain WB, IF, IHC (p), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2856539
  • Antigène Voir toutes LIMK2 Anticorps
    LIMK2 (LIM Domain Kinase 2 (LIMK2))
    Reactivité
    • 58
    • 35
    • 33
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 3
    • 3
    • 2
    • 1
    Lapin
    Clonalité
    • 57
    • 1
    Polyclonal
    Conjugué
    • 47
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LIMK2 est non-conjugé
    Application
    • 49
    • 27
    • 23
    • 13
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
     Réactivité croisée
    Humain
    Attributs du produit
    Rabbit Polyclonal antibody to LIM kinase 2 (LIM domain kinase 2)
    LIM kinase 2 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human LIM kinase 2. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product LIMK2 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: 293T

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    LIMK2 (LIM Domain Kinase 2 (LIMK2))
    Autre désignation
    LIM domain kinase 2 (LIMK2 Produits)
    Synonymes
    anticorps xlimk2, anticorps zgc:91990, anticorps wu:fa97c09, anticorps wu:fk73e11, anticorps LIMK2, anticorps Limk2b, anticorps Link2, anticorps LIMK, anticorps 9430059K01, anticorps A930024P04Rik, anticorps C85310, anticorps Limk2a, anticorps LIM domain kinase 2 L homeolog, anticorps LIM domain kinase 2, anticorps LIM motif-containing protein kinase 2, anticorps limk2.L, anticorps limk2, anticorps LIMK2, anticorps Limk2
    Sujet
    There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

    Cellular Localization: Isoform LIMK2a: Cytoplasm , Nucleus , Isoform LIMK2b: Cytoplasm
    Poids moléculaire
    72 kDa
    ID gène
    3985
    UniProt
    P53671
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