H2AFZ anticorps (N-Term)

N° du produit ABIN2856590

Détail du produit anti-H2AFZ anticorps

Antigène: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H2AFZ est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Whole Mount) (IHC (wm))

Réactivité croisée: Humain, Poisson zèbre (Danio rerio)

Attributs du produit: Rabbit Polyclonal antibody to Histone H2A.Z (H2A histone family, member Z)
Histone H2A.Z antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Histone H2A.Z. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Jurkat

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.52 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-H2AFZ (ABIN2856590)

Piquet, Le Parc, Bai, Chevallier, Adam, Polo: "The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage." dans: Molecular cell, Vol. 72, Issue 5, pp. 888-901.e7, (2018) (PubMed).

Détails sur H2AFZ

Antigène: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Autre désignation: H2A histone family member Z (H2AFZ Produits)

Synonymes: anticorps H2A.Z-1, anticorps H2A.z, anticorps H2A/z, anticorps H2AZ, anticorps H2A.Z, anticorps H2a.z-1, anticorps H2AFV, anticorps H2Az, anticorps XH2AZ, anticorps h2a.zl1, anticorps h2a.zl2, anticorps H2A histone family member Z, anticorps H2A histone family, member Z, anticorps H2A histone family member Z L homeolog, anticorps histone H2A.Z, anticorps H2AFZ, anticorps H2afz, anticorps h2afz.L

Sujet: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Cellular Localization: Nucleus

Poids moléculaire: 14 kDa

ID gène: 3015

UniProt: P0C0S5

Pathways: Telomere Maintenance