SSRP1 anticorps

N° du produit ABIN2856824

Détail du produit anti-SSRP1 anticorps

Antigène: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SSRP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Knockdown/Knockout validation was supported by references (PMID:26990993)

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to SSRP1 (structure specific recognition protein 1)
SSRP1 antibody [N1N3]

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the center region of human SSRP1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Molt-4 , 293T , A431 , HeLa , HepG2 , Jurkat

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur SSRP1

Antigène: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Autre désignation: structure specific recognition protein 1 (SSRP1 Produits)

Synonymes: anticorps ATHMG, anticorps NFD, anticorps NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR D, anticorps SSRP1, anticorps high mobility group, anticorps ssrp1, anticorps CG4817, anticorps Cf5, anticorps Dmel\\CG4817, anticorps DssRP, anticorps SSRP, anticorps dSSRP, anticorps dSSRP1, anticorps dSsrp, anticorps ssrp, anticorps Ssrp1, anticorps DDBDRAFT_0188842, anticorps DDBDRAFT_0216434, anticorps DDB_0188842, anticorps DDB_0216434, anticorps wu:fa11b03, anticorps wu:fd10f06, anticorps FACT, anticorps FACT80, anticorps T160, anticorps CIIDBP, anticorps C81323, anticorps Hmg1-rs1, anticorps Hmgi-rs3, anticorps Hmgox, anticorps high mobility group, anticorps FACT complex subunit Ssrp1, anticorps FACT complex subunit SSRP1, anticorps Structure specific recognition protein, anticorps structure specific recognition protein 1, anticorps transcription factor protein, anticorps structure specific recognition protein 1a, anticorps SSRP1 protein, anticorps structure specific recognition protein 1 S homeolog, anticorps HMG, anticorps CpipJ_CPIJ002953, anticorps CpipJ_CPIJ020011, anticorps CMU_019430, anticorps Tsp_07406, anticorps LOC100286423, anticorps Ssrp, anticorps ssrp1, anticorps SSRP1, anticorps ssrp1a, anticorps nfd110, anticorps ssrp1.S, anticorps Ssrp1

Sujet: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Cellular Localization: Nucleus

Poids moléculaire: 81 kDa

ID gène: 6749

UniProt: Q08945

Pathways: Chromatin Binding