RORA anticorps

N° du produit ABIN2857022

Détail du produit anti-RORA anticorps

Antigène: RORA (RAR-Related Orphan Receptor A (RORA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RORA est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to ROR alpha (RAR-related orphan receptor A)
ROR alpha antibody [N2N3]

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ROR alpha. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Mouse brain , HeLa , NIH-3T3

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-RORA (ABIN2857022)

Luo, Wang, Yeh, Sun, Liang, Xiao, Xu, Niu, Cheng, Maity, Jiang, Chang: "LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling." dans: Nature communications, Vol. 10, Issue 1, pp. 2571, (2019) (PubMed).

Brożyna, Jóźwicki, Skobowiat, Jetten, Slominski: "RORα and RORγ expression inversely correlates with human melanoma progression." dans: Oncotarget, Vol. 7, Issue 39, pp. 63261-63282, (2018) (PubMed).

Détails sur RORA

Antigène: RORA (RAR-Related Orphan Receptor A (RORA))

Autre désignation: RAR related orphan receptor A (RORA Produits)

Sujet: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Poids moléculaire: 63 kDa

ID gène: 6095

UniProt: P35398

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha