UVRAG anticorps (HRP)

N° du produit ABIN2868823

Détail du produit anti-UVRAG anticorps (HRP)

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UVRAG est conjugé à/à la HRP

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Predicted molecular weight at ~78.1 kDa. Observed molecular weights in the 75-90 kDa range.

Réactivité croisée: Humain, Souris, Rat

Purification: Peptide Affinity Purified

Immunogène: Synthetic peptide from the mid-protein of human UVRAG

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN2868823 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur UVRAG

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Autre désignation: UVRAG (UVRAG Produits)

Synonymes: anticorps DHTX, anticorps VPS38, anticorps p63, anticorps 9530039D02Rik, anticorps AI648770, anticorps BB124205, anticorps Uvrag1, anticorps Uvragl, anticorps zgc:56164, anticorps uvrag, anticorps MGC81810, anticorps UVRAG, anticorps MGC131135, anticorps CG6116, anticorps Dmel\\CG6116, anticorps UV radiation resistance associated, anticorps UV radiation resistance associated gene, anticorps UV radiation resistance associated S homeolog, anticorps UV radiation resistance associated L homeolog, anticorps UV-resistance associated gene, anticorps UVRAG, anticorps Uvrag, anticorps uvrag, anticorps uvrag.S, anticorps uvrag.L

Sujet: UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.

ID gène: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5