This antibody was established from the serum of a rabbit immunized with a peptiderepresenting the C-terminal domain of Autotaxin.Purified by peptide affinity chromatography.
Autotaxin, a member of the ENPP (Ectonucleotide pyrophospatase/phosphodiesterase) family ofectoenzymes, was originally identified as a motogen secreted by a melanoma cell line and subsequentlyreported to promote cell proliferation, cell motility, angiogenesis, and neurite retraction. Autotaxin haslysophospholipase D activity and appears to exert its effects by generation of the lipid mediatorlysophosphatidic acid (LPA) from lysophosphatidylcholine and sphingosine 1-phosphate (S1P) fromsphingosylphosphorylcholine (SPC) outside the cell.Autotaxin levels are significantly higher in cancerous tissues than in normal tissues suggesting that thisnovel extracellular protein may be involved in tumor progression.Two Autotaxin antibodies are available,KM105: Specifically reacts with a C-terminal fragment of AutotaxinKM106: Specifically reacts with an N-terminal fragment of Autotaxin