PLVAP anticorps

N° du produit ABIN298904

Détail du produit anti-PLVAP anticorps

Antigène: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PLVAP est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

Purification: Affinity purified

Immunogène:

Type of Immunogen: Native protein

Clone: MECA-32

Isotype: IgG2a

Information d'application

Indications d'application: Approved: Flo, IHC, IHC-Fr (1:25 - 1:100)

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Commentaires:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: avoid freeze thaw cycles. Store undiluted.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Références pour anticorps anti-PLVAP (ABIN298904)

Simon-Santamaria, Rinaldo, Kardas, Li, Malovic, Elvevold, McCourt, Smedsrød, Hirsch, Sørensen: "Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta." dans: PLoS ONE, Vol. 9, Issue 11, pp. e111762, (2015) (PubMed).

Détails sur PLVAP

Antigène: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Autre désignation: PV1 / PLVAP (PLVAP Produits)

Synonymes: anticorps MECA32, anticorps Pv1, anticorps FELS, anticorps PV-1, anticorps PV1, anticorps gp68, anticorps plasmalemma vesicle associated protein, anticorps Plvap, anticorps PLVAP

Sujet: Name/Gene ID: PLVAP

Synonyms: PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1

ID gène: 83483

UniProt: Q9BX97