APEX1 anticorps (AA 1-318)

N° du produit ABIN3015421

Détail du produit anti-APEX1 anticorps

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Épitope: AA 1-318

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APEX1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS ENKLPAELQE LPGLSHQYWS APSDKEGYSG VGLLSRQCPL KVSYGIGDEE HDQEGRVIVA EFDSFVLVTA YVPNAGRGLV RLEYRQRWDE AFRKFLKGLA SRKPLVLCGD LNVAHEEIDL RNPKGNKKNA GFTPQERQGF GELLQAVPLA DSFRHLYPNT PYAYTFWTYM MNARSKNVGW RLDYFLLSHS LLPALCDSKI RSKALGSDHC PITLYLAL

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1/APE1 (NP_542380.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-APEX1 (ABIN3015421)

Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner." dans: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 2, pp. 269-76, (2015) (PubMed).

Détails sur APEX1

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Autre désignation: APEX1 (APEX1 Produits)

Synonymes: anticorps apex1, anticorps MGC76280, anticorps MGC79645, anticorps MGC78928, anticorps APE, anticorps APE1, anticorps APEN, anticorps APEX, anticorps APX, anticorps HAP1, anticorps REF1, anticorps Apex, anticorps REF-1, anticorps BAP1, anticorps apex1a, anticorps hm:zehn1532, anticorps wu:fc13d11, anticorps zgc:66204, anticorps Ref-1, anticorps apurinic/apyrimidinic endodeoxyribonuclease 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog, anticorps DNA-(apurinic or apyrimidinic site) lyase, anticorps apurinic/apyrimidinic endonuclease 1, anticorps APEX1, anticorps apex1, anticorps apex1.L, anticorps CNG03640, anticorps CNH01280, anticorps nth, anticorps Spirs_4119, anticorps Palpr_0103, anticorps Apex1

Sujet: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.,APEX1,APE,APE1,APEN,APEX,APX,HAP1,REF1,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cardiovascular,Heart,Cardiogenesis,APEX1

Poids moléculaire: 35 kDa

ID gène: 328

UniProt: P27695

Pathways: Réparation de l'ADN, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus