FMO3 anticorps (AA 263-532)

N° du produit ABIN3015686

Détail du produit anti-FMO3 anticorps

Antigène: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Épitope: AA 263-532

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FMO3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: RFKHENYGLM PLNGVLRKEP VFNDELPASI LCGIVSVKPN VKEFTETSAI FEDGTIFEGI DCVIFATGYS FAYPFLDESI IKSRNNEIIL FKGVFPPLLE KSTIAVIGFV QSLGAAIPTV DLQSRWAAQV IKGTCTLPSM EDMMNDINEK MEKKRKWFGK SETIQTDYIV YMDELSSFIG AKPNIPWLFL TDPKLAMEVY FGPCSPYQFR LVGPGQWPGA RNAILTQWDR SLKPMQTRVV GRLQKPCFFF HWLKLFAIPI LLIAVFLVLT

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:10 - 1:100

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FMO3

Antigène: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Autre désignation: FMO3 (FMO3 Produits)

Sujet: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.,FMO3,FMOII,TMAU,dJ127D3.1,Signal Transduction,Endocrine & Metabolism,Drug metabolism,FMO3

Poids moléculaire: 60 kDa

ID gène: 2328

UniProt: P31513