GPX4 anticorps (AA 30-197)

N° du produit ABIN3015730

Détail du produit anti-GPX4 anticorps

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Épitope: AA 30-197

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Séquence: ASRDDWRCAR SMHEFSAKDI DGHMVNLDKY RGFVCIVTNV ASQUGKTEVN YTQLVDLHAR YAECGLRILA FPCNQFGKQE PGSNEEIKEF AAGYNVKFDM FSKICVNGDD AHPLWKWMKI QPKGKGILGN AIKWNFTKFL IDKNGCVVKR YGPMEEPLVI EKDLPHYF

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 30-197 of human GPX4 (NP_002076.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-GPX4 (ABIN3015730)

Wang, Zheng, Zhang, Zhao, Wang, Wang, Shang, Barasch, Qiu: "Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury." dans: American journal of physiology. Renal physiology, Vol. 315, Issue 4, pp. F1042-F1057, (2018) (PubMed).

Détails sur GPX4

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Autre désignation: GPX4 (GPX4 Produits)

Synonymes: anticorps GPx-4, anticorps GSHPx-4, anticorps MCSP, anticorps PHGPx, anticorps snGPx, anticorps snPHGPx, anticorps Phgpx, anticorps gpx-4, anticorps snGpx, anticorps cb563, anticorps cb691, anticorps PHGPxa, anticorps sb:cb563, anticorps zgc:92253, anticorps wu:fb82e03, anticorps 1700027O09Rik, anticorps mtPHGPx, anticorps ATGPX4, anticorps F11L15.5, anticorps glutathione peroxidase 4, anticorps GP-GPx4, anticorps glutathione peroxidase 4, anticorps glutathione peroxidase 4a, anticorps GPX4, anticorps Gpx4, anticorps gpx4a

Sujet: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development, thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.,GPX4,GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,GPX4

Poids moléculaire: 19 kDa/22 kDa

ID gène: 2879

UniProt: P36969